منابع مشابه
SIRT7 clears the way for DNA repair.
Histone modification by reversible lysine acetylation is a key regulatory mechanism in chromatin and nuclear signaling, whose deregulation is linked to aging, cancer, and other diseases. New work by Vazquez et al (2016) uncovers a role for the sirtuin family deacetylase SIRT7, which controls epigenetic maintenance of oncogenic gene expression programs, mitochondrial homeostasis, and ribosome bi...
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Thank you again for submitting your manuscript EMBOJ-2015-93499, "SIRT7 promotes genome integrity by regulating non-homologous end joining DNA repair". We have now received the reports of four expert referees, which I am enclosing copied below. As you will see, the reviewers express interest in the various new findings in your study, yet they also raise a number of substantive concerns regardin...
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The two co-activators of the anaphase-promoting complex/cyclosome (APC/C), Cdc20 and Cdh1, facilitate ubiquitination by the core complex, but their role in conferring substrate specificity has been contentious. A new report reveals that Cdc20-bound APC/C initiates the timely proteolysis of many Cdh1 substrates with the exception of the Aurora kinases. Failure to degrade Aurora kinases results i...
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Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2016
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201694904